The demand for natural-looking, healthy skin has never been stronger. More people are moving away from fillers that only add volume and turning toward skin boosters that help the skin repair itself from within. This shift has given rise to new-generation collagen injections in Korea, such as Rejuran and Juvelook, both designed to rejuvenate the skin by stimulating its natural collagen and healing processes.

Although they share the same goal, these two skin booster treatments work in very different ways. Rejuran focuses on deep repair, hydration, and improving overall skin texture, while Juvelook rebuilds structure and elasticity over time through long-term collagen stimulation.

With both promising to rejuvenate and restore your complexion, it’s natural to wonder which one truly delivers better results. In this Rejuran vs Juvelook comparison, we’ll take a closer look at how each treatment works, the benefits you can expect, and how to decide which option best suits your skin goals.

What is Rejuran?

Rejuran, often referred to as Rejuran Healer, is a regenerative skin booster designed to help your skin regain its natural balance and vitality. It uses a key ingredient called polynucleotides (PN), derived from salmon DNA, which work deep within the skin to stimulate repair, regeneration, and collagen production. By activating fibroblast cells, Rejuran encourages the formation of new collagen and elastin, helping the skin become smoother, firmer, and more resilient over time.

Unlike traditional fillers, which simply add volume, Rejuran focuses on healing and restoring the natural glow of your skin. It helps to strengthen your skin barrier, gives you a hydration boost, and even reduces redness for a smoother, healthier-looking complexion.

If you're looking for a treatment that can help with:

→ Dull, thin, or damaged skin

→ Softening of fine lines and early signs of aging

→ A stronger skin barrier and better hydration

→ Smoother texture and refined pores

→ Relief from redness and sensitivity

→ A genuinely natural-looking glow that lasts

Then Rejuran could be the one for you.

What Is Juvelook?

Juvelook is a hybrid biostimulatory skin booster that blends poly-D,L-lactic acid (PDLLA) and hyaluronic acid (HA) in one formula. The HA component gives immediate hydration and plumping, while the PDLLA works deeper over time to stimulate new collagen formation.

When you get a Juvelook treatment, it's the start of a longer-term process of rebuilding the structure and firmness of your skin. You won't see the results overnight - but over weeks, you can expect your skin texture, elasticity and radiance to improve. And this treatment is especially suited for people dealing with:

• Acne scars

• Fine lines

• Mild sagging

• Uneven texture

The reason Juvelook is gaining so much popularity is that it offers both short-term hydration and long-term structural support, which can really help give your skin a smoother, firmer look.

If you're looking for a treatment that can give you:

→ Gradual improvement rather than sudden volume changes

→ A smoother, firmer skin texture

→ A natural reduction in fine lines and mild sagging

→ Better appearance of acne scars and uneven skin

→ More lasting collagen support without having to resort to harsh fillers

Then Juvelook could be the one for you.

Both Rejuran and Juvelook are designed to give you better-looking skin through collagen stimulation - but they work in unique ways. Rejuran's polynucleotides (PN) are all about cellular repair - getting your skin to start healing and repairing itself from the inside out. Juvelook's polylactic acid (PLA), on the other hand, is all about stimulating new collagen formation - while also giving you a hydration boost and some volumizing effects.

In the end, Rejuran is all about strengthening and healing your skin from the inside out, while Juvelook is all about rebuilding the structure and elasticity of your skin over time. And the best bit? Lots of patients are using both treatments at different stages of their skin care journey because they really do complement each other and address different layers of skin concerns.

Treatment Experience & Recovery

Both Rejuran and Juvelook are performed through a series of microinjections, placed evenly across the face in a pattern similar to microneedling. This technique allows the solution to reach just beneath the skin’s surface, where it can trigger regeneration and collagen formation.

Before treatment, a numbing cream is applied to ensure comfort. Most people describe the sensation as mild pinching or slight pressure, making the procedure quite tolerable.

Revised: Most people find Juvelook fairly comfortable, with only mild pinching or pressure. Rejuran can feel a bit more intense, though practitioners take steps to keep you comfortable throughout the procedure.

Afterward, you may notice:

→ Light redness or tiny bumps at the injection sites

→ Mild swelling that fades within one to two days

→ A gentle feeling of tightness with Juvelook as collagen production begins

To support recovery, keep your skincare simple for a few days.

Focus on:

→ Hydration to soothe and restore balance

→ Sun protection to prevent irritation

→ Avoiding active ingredients or exfoliation until the skin settles

Following these steps helps your skin heal smoothly and enhances the glow that develops in the weeks after treatment.

Results and Longevity

Rejuran and Juvelook both deliver gradual, natural-looking improvements rather than instant results. With Rejuran, you can expect to see a healthier glow and smoother texture within 2 to 4 weeks, as the skin begins to repair and strengthen from within. Juvelook, on the other hand, builds results more slowly, showing visible firmness and lift after 4 to 8 weeks as collagen continues to form.

Rejuran typically requires 3 to 4 sessions, spaced about 3 to 4 weeks apart, to achieve optimal results. Juvelook may need fewer sessions because its collagen-stimulating effects last longer.

Depending on your skin condition and aftercare, the results of both treatments can last between 6 to 12 months. Consistent hydration, sun protection, and follow-up treatments are key to maintaining long-term improvements and keeping the skin firm, balanced, and radiant.

Which One Should You Choose?

Each treatment offers its own strengths, so your choice depends on your skin’s current needs and long-term goals.

Choose Rejuran if:

1. You want to repair your skin barrier and improve hydration
2. You struggle with redness, sensitivity, or dullness
3. You prefer a treatment that focuses on healing and strengthening the skin

Choose Juvelook if:

1. You want to smooth acne scars and fine lines
2. You’re targeting mild sagging or loss of elasticity
3. You prefer a longer-lasting collagen boost

Some clinics even recommend a combination approach, using both treatments for layered rejuvenation. Your age, skin sensitivity, and lifestyle can also influence what works best.

For the best results, always consult a licensed dermatologist from one of our trusted clinics. You can also take the AI Skin Test to better understand your skin type before choosing your next treatment.

Your Skin, Your Choice — But Here’s What Matters Most

When it comes to Rejuran vs. Juvelook, there isn’t a clear winner—each treatment offers unique benefits depending on your skin’s needs. Rejuran focuses on repairing and strengthening the skin from within while also promoting natural collagen renewal for a healthier, more resilient complexion. Juvelook, on the other hand, enhances collagen production more deeply to smooth texture and improve firmness. Both can beautifully complement each other for long-term rejuvenation.

Both can beautifully complement one another for long-term rejuvenation.

To better understand how each treatment works and what makes them unique, read our full guides on Rejuran and Juvelook.

FAQs

1. Can I switch from Rejuran to Juvelook?

Yes, you can switch treatments depending on your skin goals and progress. Many people start with Rejuran to repair and strengthen the skin barrier, then move to Juvelook for deeper collagen stimulation and firmness.

2. Which treatment is better for acne scars?

Juvelook is generally preferred for acne scars because its PLA component rebuilds collagen and fills depressed areas. Rejuran, however, can improve skin texture and redness, making it a great supportive treatment for healing and maintenance

If your main goal is to target acne scars more intensively, you may also want to explore laser-based options like Fraxel, which directly resurface and renew damaged skin.

Learn more in our guide: What Is Fraxel Laser? A Complete Guide to Treating Acne Scars, Sun Spots, and Wrinkles

3. How soon can I wear makeup after the procedure?

It’s best to wait at least 24 hours before applying makeup to allow the skin to calm and heal. This helps reduce the risk of irritation or infection after microinjections.

4. Does either treatment cause swelling or bumps?

Mild swelling or tiny bumps can appear after both treatments, but they typically subside within a few days. These are normal signs that your skin is responding and healing, although recovery may take longer depending on the individual.

5. Is the procedure painful?

Most people describe it as mildly uncomfortable rather than painful. However, Rejuran can feel more intense for some individuals, even with numbing cream, because of its deeper injection technique. The procedure itself is relatively quick, and any lingering sensitivity usually eases on its own. An experienced provider can also adjust techniques to make the process as comfortable as possible.